As we all expected the doctor escaped death, I have some questions I will list:
Is the marriage real? I mean it was a teslasector and he didn't actually tell her his name plus the whole alternate time stream..... I am thinking better wedding to come.
Who blew up the Tardis? I feel like the answer to this is going to introduce a whole new set of plot. Maybe to arch back and tie up some more loose ends, maybe on to greener pastures like 50th ani.
Will the Doctor eventually retrieve River from the Library? I know that seems like a sort of silly question but if he took the time to save her onto the hard drive of Cal my thought has always been that he wasn't intending to leave her there. Now I don't think he can. You know how pissed River would be if he did that. I also think it is fairly obvious now that he already does but will even more so really and truly love her, he promised not to mess up their time stream up-to that point at the library but its one of those things where I feel like if he doesn't find a way to retrieve her their whole relationship will be sort-of invalidated. the only exception to this would be if his final and real death was coming soon after, in which case I think it would be kindof cruel to leave her there for eternity without him in a virtual world.
Why did they ask a asinine question like that? I get it pun and what not but there has to be more substance to it that we haven't gleaned yet. I won't speculate further atm, after I have re-watched all of 5 and 6 plus the ten/river eps I will try to come up with some conclusive theories.
On that note why does the Silence not want the question answered? That has to be the bigger more obvious question.
Why didn't Rory have memories from the alternate time stream? We know River, The Doctor and Amy could all see the different time streams at once, River and the doctor because they were the cause of it and Amy because of the whole crack in her wall thing, but Madame Kovarian was aware as well and she had no reason to be.

Amy and Rory don't seem that pissed about their baby being stolen, why? I know people think this has been addressed but I still think they need to sort of have some kind of show for the audience if that is how they intend to play it. Now that the Plot arch has had some tension release they will have to address it. Obviously nothing can be changed because it would jack up all the shit that has happen.
Will the River-Doctor thing change the River-Amy-The Doctor- Rory dynamic? Up until now it has all been harmless flirting but now it won't be and that seems like it is going to freak Amy and Rory out a bit. Alternatively River and The Doctor might tone it down, but where would the fun be in that?
The last thing I have to add isn't a question but more of a hope that they do right by this character of River Song. I do love the idea of her immensely but more then that I think she has been a long time coming. I believe Doctor Who will one day have to come to its finial end and so for us the audience we need her to believe that the Doctor had some final happiness. I know a lot of people don't agree but I think to preserve what was so loved about it, it will eventually have to end. After the movie with 8 things ended but they weren't finished, there were still ways for the doctor to return, still so many unfinished plot lines and characters still floating out there, when it is really over we will know. The main reason for Moffat introducing her is that the Doctor has changed, he had to. He has always been changing in slow an subtle ways but he had to grow, he couldn't be static and still be loved. We are realist, we know The Doctor wont be living in a fairy tale happily ever after when the show ends, he will die utterly and permanently and it will probably be for us, a sacrifice. But before that happens he has to really heal a little from his past guilt and move towards happiness or some semblance of. River might not be his final love but she represents something changing in the Doctor like we have never seen before. Hope, that he could be a little bit truly happy. Ultimately Doctor Who is a tragedy, any one who has watched it see that. What we don't know is how it will end.
On a side note: Sometimes no one notices when you are really and truly depressed and having a hard time in life.